Traditional Chinese Medicine, Cancer Management Session

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Integrative oncology is the integration of traditional and non-traditional forms of medicine in the treatment of cancer. This approach to cancer care is an alternative to conventional treatments such as chemotherapy, radiation, and surgery. It combines the principles of clinical medicine, “complementary and alternative” therapies, scientific research, and the patient’s individual needs. Integrative oncology may include lifestyle and dietary modifications, physical activities, stress management, botanical medicine, acupuncture, massage, yoga, professional counseling, and other modalities. The goal of integrative oncology is to improve quality of life for cancer patients by focusing on the whole person – body, mind, and spirit. Research has demonstrated that this type of holistic approach can help manage the physical, emotional, mental, and spiritual side effects of cancer treatments. Integrative oncology has also been shown to be effective in reducing pain and fatigue, bolstering immunity, promoting sleep, and controlling underlying conditions (such as insomnia or anxiety). Integrative oncology is not meant to replace conventional therapies; instead, it is designed to complement them. Properly trained practitioners can provide comprehensive care for the patient that includes conventional treatments as well as evidence-based complementary and alternative medicine (CAM)

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The practice of Yoga is mainly adopted to keep harmony between the body and the mind. The literal meaning of Yoga is ‘union’, which means union of the body and the mind. Various body postures with meditation and breathing exercises are a part of Yoga, and this practice is performed in India for thousands of years. Ashtanga Yoga includes eight limbs or eight stages of Yoga which helps in attaining mental, physical, and spiritual well-being in humans by regularly practising it. Yoga practice can cure many diseases, and it is beneficial in cancer patients who have received chemotherapy and radiation therapy. Fatigue, body pain, psychological stress is associated with cancer patients undergoing therapies, and Yoga practice is found to alleviate these symptoms in patients and promotes quick recovery. Many randomized control trials have been done to show the beneficial effects of Yoga in cancer patients, irrespective of the type of cancer that caused the disease. This chapter discusses the effects of Yoga practice in cancer patients and underscores the importance of Yoga in cancer therapy.

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Raditional medicine and natural products have recently gained interest and have become a matter of great importance. The traditional medicines are rooted to Ayurveda, Traditional Chinese medicine, traditional Korean medicine, Kampo and Unani, which were practised previously and are still used in a few parts of the world. Plants are a vital source of herbal and synthetic agents used by various pharmaceutical industries. Some plant metabolites have found clinical applications as anti-cancer agents such as paclitaxel (taxol), topotecan, vinblastine and vincristine. In India, Himalayas is one of the world biodiversity hotspots harbouring various pervasive medicinal plants. Despite comprehending of the literature regarding ethnopharmacological information of medicinal plant, but information of some pervasive medicinal plant is still being exploited. In the past few decades, herbal medicine has gained popularity worldwide and emerged as the opportunity to promote traditional Indian medicine globally. Now, people from various developing and developed countries have gained interest in Himalayan herbal medicines. Hence, this chapter aims to provide an overview about the importance of herbal medicine and provide the information about the medicinal plants with anti-cancerous potential.

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Globally, cancer has become a second major cause of human mortality rate, which significantly affects the human population. Therefore, a constant demand is kept for new therapies to treat and cure this severe disease. Due to less toxic side effects in comparison to existing treatment such as chemotherapy, herbal medicine has been drawn consideration in many diseases cure and treatment. Now with due attention, traditional medicine from herbal plants is admired for cancer treatment as of their potent anticancer effects. Plant secondary metabolites such as polyphenols, flavonoids, among others, have potent anti-cancer properties and have been explored for cancer treatment for centuries. Many studies have revealed that these secondary metabolites possess effective anticancer activities by exhibiting several different mechanisms such as antioxidant activity, apoptosis induction, target specificity, prevention to DNA damage, cell cycle regression, angiogenesis prevention. Therefore, herbal plants and their naturally derived compounds become potential drugs for cancer cure and treatment.

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It is essential to be aware of the advances in the nutritional aspects of cancer for oncology practitioners. Unlike the popular myth, the term “Cachexia” more effectively defines the present status in oncology patients rather than “cancer-related malnutrition” (CRM). The consensus guidelines recommend the usage of management algorithm, staging of the CRM involving screening for the nutritional risk and devising a management strategy consistent with a phenotype and the staging. There should be an inclusion of preventive measures for the CRM in the management algorithm like pharmacological and non-pharmacological interventions aiming both anabolic and the anti-catabolic measures as well as repeated checking of the status of Nutrition. At present, the multimodal mechanism is the optimum method to battle catabolic resulting in CRM. This method should be simultaneously given with anticancer treatments and involve pharmaconutrients, nutritional intervention and the multiple target drug treatments and physical activity. This article provides the practitioners with an awareness of the recent development in the area of nutritional care and as well as defined guidelines to regulate cancer therapy during treatment. This book chapter thus gives insightful guidelines pointing on crucial aspects of Nutrition for cancer treatment.

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With the advancement in the sequencing technology, diagnosis, and new treatment methods in the field of oncology arises some new challenges to analyze such big data generated as a result. These challenges also lead to alternative approaches by which it can be solved. One such approach is the use of computational technology in the field to analyze, predict and respond with high accuracy to the problem. With the use of many web-based and offline computational tools, it now becomes easier to analyze and predict the result with high accuracy that could not be possible by using the human brain only. This book chapter summarizes some of these such tools related to analyzing multi-omic cancer molecular data, biomarker discovery, digital pathology tools for diagnosis and image deconvolution tools in the field of clinical oncology.

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Novel molecular imaging techniques are direct or indirect visualising methods which complement the various approaches be it diagnostic or therapeutic. These techniques are gaining immense recognition as they are proving to be a powerful tool with the scope of improving every aspect of cancer care. Molecular imaging is a non-invasive technique of visualising the molecules and events related to it that form the basis of human tumor biology. Today various advanced molecular enhancers have been developed for visualising the molecular events in the human body efficiently and accurately. These include Ultrasound, PET, SPECT, MRI and Optical imaging which may assist in the rapid and more efficient diagnosis and grading of tumors which are fundamental for early and productive therapeutic response. The smart molecular imaging techniques not only allow localisation of tumors but also detect the expression levels and the altered functions of distinct proteins. Imaging can also help in looking for various activities which are hallmarks of cancer such as apoptosis, angiogenesis, and metastasis that are responsible for its altered biology and their therapeutic response. “Smart” molecular probes developed in molecular imaging seem encouraging for their potential to visualise tumor lesions before its resection and after, without reinjecting the probe to monitor the outcome or the effects of its removal. Additionally, dual labelling with fluorescent dyes of molecular MR probes may instigate simultaneous assistance during surgical resection, thus augmenting complete removal and preservation of important structures. Therefore, a correct combination of therapeutic and diagnostic approach is the requisite need of the hour.

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Cancer is the condition when the cells proliferate at uncontrollable rates and the wrong locations. Cancer research is a prime property in the real-estate of science with immense potential of success. Regenerative medicine deals with the regeneration of new cells to replace damaged or mutated cells, which requires the understanding of growth-related pathways and molecular mechanisms of tumorigenesis. Stem cells have proven useful in cancer therapies, at least in those cancers, for which the stem cell markers have been identified. Induced pluripotency is an amicable solution for the cancers in which these markers are not significantly expressed. Genetic reprogramming of somatic cells to produce stem cells has been a magic bullet for regenerative medicine. The chapter presents the salient aspects of regenerative medicine and the potential of stem cells for cancer therapies.

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Chinese Medicine (CM) has been used for several thousand years, playing an important role in the prevention and treatment of diseases including cancer. In the recent four decades, a number of CM herbs have aroused extreme interest in the world—isolating anticancer components from medicinal herbs, using them as biological response modifiers, and most recently as angiogenesis inhibitors. The present review reports both the experimental and clinical results obtained in the field of clinical oncology, especially conducted by our group. The review also presents the possible future of integration of CM and modern medicine in basic research and clinical practice, especially when CM used as adjuvant and maintenance therapy.

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Patients with cancer pursue all possible opportunities of effective remedies. In Saudi Arabia, most patients have tried complementary medicine during their cancer treatment plan; however, some complementary medicines might pose a danger to health. In Arab countries, studies regarding the use of complementary medicines and the intentions behind using complementary medicines among cancer patients are inadequate and all but nonexistent. The aim of this review was to focus on demographic, prevalence, and reasons for complementary and alternative medicine use among patients with cancer.

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Chinese medicine, developed over millennia, forms a comprehensive healthcare system in China. It involves diverse traditional practices, most prominently traditional Chinese medicine. TCM incorporates acupuncture, herbal medicine, massage (Tui Na), dietary therapy, and exercises like Tai Chi and Qi Gong. Fundamental principles revolve around balancing the body’s vital energy, known as Qi, and attaining harmony between opposing forces, such as Yin and Yang. This approach perceives the body as an interconnected system where imbalances result in illness and treatments strive to re-establish equilibrium, promoting overall well-being.

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Traditional medicine is a cultural repository of knowledge and practices, spanning diverse methods to maintain health and address physical and mental conditions. While some systems are well documented, others pass down orally through generations. Globally, a substantial population depends on traditional medicine for primary healthcare, gaining popularity even in countries dominated by conventional medications. Notable systems, such as traditional Korean, Japanese, Chinese, African, and Indian medicine, embody unique cultural practices. Authentication is crucial for sustaining the continued relevance of these traditions.

Traditional Korean Medicine

Traditional Japanese Medicine

Traditional Indian Medicine.

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Alternative Therapies explores non-conventional approaches to alleviate and manage pain, distinct from traditional medical interventions. These integrative therapies often focus on holistic well-being, addressing physical, mental, and emotional aspects. The goal is to offer diverse options that complement or substitute conventional pain treatments, fostering a more comprehensive and patient-centred approach to pain management. This aim is to evaluate efficacy, safety, and the integration of alternative therapies into mainstream healthcare for improved pain relief. Examples include:

  • Acupuncture
  • Chiropractic care
  • Massage therapy
  • Herbal remedies.

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Biotechnology plays a pivotal role in the realm of Naturopathic medicines by facilitating the discovery, development, and production of herbal remedies and bioactive compounds. It enables the identification of novel therapeutic agents through genetic screening and metabolic profiling, as well as the large-scale cultivation of medicinal plants and the sustainable production of bioactive ingredients. Biotechnology-driven pharmacogenomics tailors’ herbal treatments to individuals’ genetic profiles, improving efficacy and safety. Moreover, it ensures quality control through DNA barcoding and authentication, and it contributes to innovative formulations and drug delivery systems. Safety assessments, advanced biological assays, and sustainable cultivation practices are also facilitated by biotechnology, supporting the integration of natural medicines into modern healthcare while promoting environmental sustainability.

The Naturopathic Medicine 2024 conference will feature a session on the role of Biotechnology in Natural Medicines. Biotechnology has revolutionized the field of medicine, and the application of Biotechnology in natural medicine has led to significant advancements in the development of new and effective therapies. The session will focus on the latest research and developments in Biotechnology, including the use of Genetic Engineering, Tissue engineering, and Stem Cell Technology to enhance the production and efficacy of natural medicines. Attendees will have the opportunity to learn about the latest developments in Biotechnology and Traditional medicine, network with other professionals, and gain valuable insights into the future of Traditioal medicine.

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The use of herbal medicine by patients with cancer may result in potentially negative effects that can impact the efficacy and safety of conventional anticancer treatments. Greater than 35% of patients with cancer in the United States report using herbal medicine during chemotherapy, with this rate exceeding 50% in developing countries.1, 2 Between 20% and 70% of patients using complementary and traditional medicine (CTM), including herbal agents, are often reluctant to disclose this practice to their conventional medical professional.

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Herbal medicine is a complementary therapy that some people with cancer use to ease cancer symptoms and relieve treatment side effects. Mesothelioma patients should discuss herbal medicine with their doctor to avoid drug interactions and negative treatment consequences.

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